Thymoquinone Preserves Pancreatic Islets Structure Through Upregulation of Pancreatic β-Catenin in Hypothyroid Rats

Diabetes Metab Syndr Obes. 2021 Jun 29;14:2913-2924. doi: 10.2147/DMSO.S317417. eCollection 2021. ABSTRACT BACKGROUND: Altered status of thyroid hormones, which have a key role in regulating metabolism, was reported to affect glucose homeostasis and insulin secretion. OBJECTIVE: This study was designed to assess the impact of propylthiouracil (PTU)-induced hypothyroidism on the pancreatic islet cells and the […]

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Therapeutic effects of thymoquinone or capsaicin on acrylamide-induced reproductive toxicity in rats mediated by their effect on oxidative stress, inflammation, and tight junction integrity

Drug Chem Toxicol. 2021 Jul 7:1-13. doi: 10.1080/01480545.2021.1942485. Online ahead of print. ABSTRACT In the field of environmental toxicology, endocrine-disrupting effects have become a major concern. The present research set out to investigate the possible reproductive toxicity of acrylamide. The research was also expanded to explore the protective effects of two nutraceuticals, thymoquinone (TQ) and […]

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Thymoquinone Preserves Pancreatic Islets Structure Through Upregulation of Pancreatic beta-Catenin in Hypothyroid Rats

Diabetes Metab Syndr Obes. 2021 Jun 29;14:2913-2924. doi: 10.2147/DMSO.S317417. eCollection 2021. ABSTRACT BACKGROUND: Altered status of thyroid hormones, which have a key role in regulating metabolism, was reported to affect glucose homeostasis and insulin secretion. OBJECTIVE: This study was designed to assess the impact of propylthiouracil (PTU)-induced hypothyroidism on the pancreatic islet cells and the […]

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Evaluating the therapeutic impact of thymoquinone toward ischemic brain injury alleviation via Nrf2/HO-1 pathway

Expert Opin Ther Targets. 2021 Jul 8. doi: 10.1080/14728222.2021.1952986. Online ahead of print. ABSTRACT BACKGROUND: : Reactive oxygen species (ROS)-mediated inflammation plays a crucial role in ischemic brain injury. Therefore, the activation of the nuclear erythroid 2 related protein and heme- oxygenase-1 (Nrf2/HO-1) pathway by thymoquinone (TQ) could ameliorate ischemic brain damage. RESEARCH DESIGN AND […]

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Green NP-HPTLC and green RP-HPTLC methods for the determination of thymoquinone: A contrast of validation parameters and greenness assessment

Phytochem Anal. 2021 Jul 5. doi: 10.1002/pca.3078. Online ahead of print. ABSTRACT INTRODUCTION: Thymoquinone (TQ) is a naturally derived bioactive compound with several therapeutic effects. OBJECTIVE: The highly sensitive, rapid and green normal-phase (NP)/reversed-phase (RP) high-performance thin-layer chromatography (HPTLC) densitometry technique was developed for the determination of TQ in various plant extracts of different geographical […]

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Antioxidants thymoquinone and eugenol alleviate TiO(2) nanoparticles induced toxicity in human blood cells in vitro

Toxicol Mech Methods. 2021 Jul 5:1-35. doi: 10.1080/15376516.2021.1949083. Online ahead of print. ABSTRACT Titanium dioxide (TiO2) nanoparticles (NPs) are used extensively in a variety of commercial, industrial and medical products, due to which human exposure is inevitable. The present study aimed to explore the potential of eugenol and thymoquinone (TQ), two well-known antioxidants, in counteracting […]

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Thymoquinone dose-dependently attenuates myocardial injury induced by isoproterenol in rats via integrated modulations of oxidative stress, inflammation, apoptosis, autophagy, and fibrosis

Naunyn Schmiedebergs Arch Pharmacol. 2021 Jul 3. doi: 10.1007/s00210-021-02087-1. Online ahead of print. ABSTRACT As rats develop myocardial infarction (MI) like lesions when injected with large doses of isoproterenol (ISO), this investigation was designed to evaluate the dose-dependent effects of thymoquinone (TQ) on ISO-induced myocardial injury in rats. Adult male rats were divided into negative […]

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Thymoquinone and its derivatives against breast cancer with HER2 positive: in silico studies of ADMET, docking and QSPR

J Basic Clin Physiol Pharmacol. 2021 Jun 25;32(4):393-401. doi: 10.1515/jbcpp-2020-0431. ABSTRACT OBJECTIVES: The high prevalence of HER2-positive breast cancer has become a significant concern in the health sector. The problem is more complex with the side effects of breast cancer drugs currently used. Thymoquinone (TQ), the main bioactive compound in Nigella sativa, has been shown […]

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Thymoquinone and its derivatives against breast cancer with HER2 positive: in silico studies of ADMET, docking and QSPR

J Basic Clin Physiol Pharmacol. 2021 Jun 25;32(4):393-401. doi: 10.1515/jbcpp-2020-0431. ABSTRACT OBJECTIVES: The high prevalence of HER2-positive breast cancer has become a significant concern in the health sector. The problem is more complex with the side effects of breast cancer drugs currently used. Thymoquinone (TQ), the main bioactive compound in Nigella sativa, has been shown […]

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