Thymoquinone Preserves Pancreatic Islets Structure Through Upregulation of Pancreatic β-Catenin in Hypothyroid Rats

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Diabetes Metab Syndr Obes. 2021 Jun 29;14:2913-2924. doi: 10.2147/DMSO.S317417. eCollection 2021. ABSTRACT BACKGROUND: Altered status of thyroid hormones, which have a key role in regulating metabolism, was reported to affect glucose homeostasis and insulin secretion. OBJECTIVE: This study was designed to assess the impact of propylthiouracil (PTU)-induced hypothyroidism on the pancreatic islet cells and the […]

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Nigella sativa callus treated with sodium azide exhibit augmented antioxidant activity and DNA damage inhibition

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Sci Rep. 2021 Jul 6;11(1):13954. doi: 10.1038/s41598-021-93370-x. ABSTRACT Nigella sativa L. (NS) is an herbaceous plant, possessing phytochemicals of therapeutic importance. Thymoquinone is one of the active phytochemicals of NS that confers noteworthy antioxidant properties. Sodium azide, an agent of abiotic stress, can modulates antioxidant system in plants. In the present investigation, sodium azide (0, […]

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Green NP-HPTLC and green RP-HPTLC methods for the determination of thymoquinone: A contrast of validation parameters and greenness assessment

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Phytochem Anal. 2021 Jul 5. doi: 10.1002/pca.3078. Online ahead of print. ABSTRACT INTRODUCTION: Thymoquinone (TQ) is a naturally derived bioactive compound with several therapeutic effects. OBJECTIVE: The highly sensitive, rapid and green normal-phase (NP)/reversed-phase (RP) high-performance thin-layer chromatography (HPTLC) densitometry technique was developed for the determination of TQ in various plant extracts of different geographical […]

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Biosynthesis of gold nanoparticles using Nigella sativa and Curtobacterium proimmune K3 and evaluation of their anticancer activity

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Mater Sci Eng C Mater Biol Appl. 2021 Aug;127:112214. doi: 10.1016/j.msec.2021.112214. Epub 2021 May 29. ABSTRACT In recent times, the development of functionalized nanoparticle methodology for biomedical applications has become a major challenge. In the present study, we prepared a novel gold nanoparticle (AuNP), named Curto-Cumin AuNP (CC-AuNP), using the biosynthetic process involving Nigella sativa […]

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Mechanistic Aspects of Medicinal Plants and Secondary Metabolites against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)

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Curr Pharm Des. 2021 Jul 5. doi: 10.2174/1381612827666210705160130. Online ahead of print. ABSTRACT BACKGROUND AND OBJECTIVE: The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), a highly pathogenic virus, is responsible for a respiratory disease termed coronavirus disease 2019 (COVID-19). SARS-CoV-2 genome encodes various structural and non-structural proteins, which are necessary for viral entry and replication. […]

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