Evaluating the therapeutic impact of thymoquinone toward ischemic brain injury alleviation via Nrf2/HO-1 pathway

Expert Opin Ther Targets. 2021 Jul 8. doi: 10.1080/14728222.2021.1952986. Online ahead of print. ABSTRACT BACKGROUND: : Reactive oxygen species (ROS)-mediated inflammation plays a crucial role in ischemic brain injury. Therefore, the activation of the nuclear erythroid 2 related protein and heme- oxygenase-1 (Nrf2/HO-1) pathway by thymoquinone (TQ) could ameliorate ischemic brain damage. RESEARCH DESIGN AND […]

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Thymoquinone Preserves Pancreatic Islets Structure Through Upregulation of Pancreatic beta-Catenin in Hypothyroid Rats

Diabetes Metab Syndr Obes. 2021 Jun 29;14:2913-2924. doi: 10.2147/DMSO.S317417. eCollection 2021. ABSTRACT BACKGROUND: Altered status of thyroid hormones, which have a key role in regulating metabolism, was reported to affect glucose homeostasis and insulin secretion. OBJECTIVE: This study was designed to assess the impact of propylthiouracil (PTU)-induced hypothyroidism on the pancreatic islet cells and the […]

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Therapeutic effects of thymoquinone or capsaicin on acrylamide-induced reproductive toxicity in rats mediated by their effect on oxidative stress, inflammation, and tight junction integrity

Drug Chem Toxicol. 2021 Jul 7:1-13. doi: 10.1080/01480545.2021.1942485. Online ahead of print. ABSTRACT In the field of environmental toxicology, endocrine-disrupting effects have become a major concern. The present research set out to investigate the possible reproductive toxicity of acrylamide. The research was also expanded to explore the protective effects of two nutraceuticals, thymoquinone (TQ) and […]

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Effects of Nigella sativa on Performance, Blood Profiles, and Antibody Titer against Newcastle Disease in Broilers

Evid Based Complement Alternat Med. 2021 Jun 14;2021:2070375. doi: 10.1155/2021/2070375. eCollection 2021. ABSTRACT Recent anxiety about resistance to chemical drugs has elevated the position of phytogenic feed additives including Nigella sativa in preventive strategy in the poultry industry. During this study, a completely randomized experiment was designed to investigate the efficacy of different levels (0 […]

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